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Jessica could refer to:
- Jessica, the name of a painting in Linderman's gallery, as seen at corinthianlasvegas.com.
- Jessica Anne Bogart, the actress who portrays an hysterical mother.
- Jessalyn Gilsig, the actress who portrays Meredith Gordon.
- Jessica Hammond, the actress who portrays a multicolor eyed carny.
- Jess Murphy, a deceased evolved human from Chandra's list.
- Jessica Sanders, Niki's sister who died in 1987.
- Jessica Sanders, one of Niki's alter egos who has the power of enhanced strength.
- Niki Sanders, the evolved human who has the power of enhanced strength.
- Future Niki Sanders, whose strips using "Jessica" as her stage name.
- Jessica Whitaker, the actress who portrays a UWHS cheerleader.
- Candice Willmer, who takes on the persona of Jessica in some of her illusions.
- Jesse -- a list of Jesses