|Portrayed by||Seth Green|
|First appearance||The Eclipse, Part 1|
|Occupation||Comic store employee|
Hiro and Ando travel to Sam's Comics in search of the newest issue of 9th Wonders!, trying to figure out what to do next. Sam calls Frack over and they are both surprised, as they look at the new issue and see themselves on the cover, looking at the same exact issue, with Hiro and Ando standing in the background.
Sam accuses Frack of playing a practical joke, but Frack insists that he is not. As Hiro struggles with what he has learned about his life, locked in the bathroom, Sam delivers an inspiring pep talk about what it takes to be a true hero, and how much what he does means to everyone. Hiro finally exits the bathroom and subsequently teleports away on his next mission. Sam then tells Ando & Matt about a story he heard, regarding a sketchbook belonging to Isaac Mendez. Apparently, it was given to a bike messenger just before his death. The sketchbook supposedly contains the framework for the final issue of 9th Wonders!. He suggests that, to find the issue, they should seek out the messenger.
- According to the November 24-December 7, 2008, issue of TV Guide, Sam is named after Sam Loeb, Jeph Loeb's son. Sam Loeb was a budding comic book writer who died of cancer in 2005 at the age of 17. He died before completing the story for Superman/Batman, Issue #26, so Jeph Loeb and 25 other industry professionals (including Joe Casey, Joe Kelly, Jim Lee, Duncan Rouleau, Tim Sale, and Michael Turner) finished writing and penciling the issue for Sam. David Moran, Peter Steigerwald, Dave Stewart, and others from Aspen Comics colored the issue. All contributors donated their fees and royalties for the issue to The Sam Loeb College Scholarship Fund. Incidentally, Seth Green dedicated Operation: Rich in Spirit, the seventeenth episode of Robot Chicken, to Sam Loeb's memory.
- According to Michael Ausiello, Sam's name was originally supposed to be "Seth".
- For other uses of Sam, see Sam (disambig).