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Barbara could refer to:
- Barbara Anders, Syn Anders's mother.
- Barbara, the triplet sister of Niki Sanders and Tracy Strauss.
- Barbara, who performs as a mermaid in a circus.
- "Barbie", Eric Doyle's nickname for Claire Bennet.
- Natalie Barbrie, a production assistant for Heroes.
- Barbie Travis, a girl who, right after the Burnt Toast Diner opened, was killed by Merle Eckels.