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Deborah could refer to:
- Deb Bohrman, number two for NSA systems procurement, who has ties to the Pinehearst Company.
- Debbie, the long-lost sister of Piper, as seen in Piper's dream.
- Debra, Charlie Andrews's best friend in elementary school.
- Deborah Franklin, Benjamin Franklin's wife.
- Debra Harding, believed to be an evolved human who can summon others for assistance, as described on the assignment tracker map.
- Debbie Marshall, a cheerleader at CVHS.
- Debra McGuire, a costume designer for Heroes.
- Deborah Tennant, the actress who portrays Mrs. Frady.