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Donna could refer to:
- Donna, an evolved human with the ability to fly.
- Donna Deitch, a director for Heroes.
- Donna "Scream" Diego, a Venom/Carnage character referenced in Hiro's blog.
- Donna Dorn, a professor at the University of Chicago, who appears in Sword Saint.
- Donna Dunlap, an evolved human with telescopic vision.
- Donna's Big Date, a series of graphic novels about Donna Dunlap.
- Penny Logan, who uses the name when she is disguised as Donna Dunlap.