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Jesse could refer to:
- Jesse Alexander, a writer and producer for Heroes.
- Jesse Corti, the actor who portrays an LAPD captain.
- Jesse Heiman, the actor who portrays a Sam's Comics patron.
- Jesse, Echo's younger half-brother who once joined the military.
- Jess Murphy, a deceased evolved human from Chandra's list.
- Jesse Murphy, an evolved human who was imprisoned on Level 5.
- Jessica -- a list of Jessicas