|First appearance||Nothing to Hide|
|Formal name||Karen Gallagher Sprague|
|Age||31 (at death)|
|Date of birth||January 29, 1975|
|Date of marriage||2004|
|Date of death||October 8th, 2006|
|Home||Los Angeles, CA|
|Residence||Karen Sprague's home|
|Occupation||2nd grade teacher|
|Significant others||Ted Sprague (husband, deceased)|
|Sibling||Joseph Gallagher (deceased)|
|Other relatives||Mindy Sprague (mother-in-law)|
Karen Sprague (née Gallagher) is the late wife of Ted Sprague.
Matt and Audrey encounter Ted and his comatose wife. She is dying of cancer, caused by her husband's radiation powers. Her oncologist, Robert Fresco, was accidentally killed by her husband. Thanks to Matt Parkman's telepathic abilities, Karen, although comatose, is able to enjoy one last moment together with her husband just before she dies.
- Karen was born on January 29, 1975, as revealed on her tombstone.
Ted visits Karen's grave.
- For other uses of Karen, see Karen (disambig).