Besides his work on Heroes, Ossie Mair has been a guest actor for many television series. His television career includes guest roles in the episodes The Prankster (1994) of Lois & Clark: The New Adventures of Superman, Humpty Dumped (2002) of NYPD Blue, the pilot episode and Who's Sari Now? (2003) of Miss Match, The Ann Who Came to Dinner (2004) of Frasier, I See Me, I.C.U. (2007) of Ugly Betty, The Boss (2008) of Samantha Who?, Slip of the Tongue (2008) of Californication, and the episodes Starving...Literally and Stealing Alan Thicke of Star-ving.
Ossie Mair has also acted in several films including playing a store clerk in For Goodness Sake (1993), "Zindagi" in My Beautiful Me (1998), a cabbie in Cheaper by the Dozen (2003), and "Dr. Stan Boyd" in the Germany-shown film American Zombie (2007).